windows - Will my programs work if I move my 'Program Files' folder and then place it back to a partition with the same label?

I need some extra space in my 'C:\' partition and for doing that I need to delete my 'D:\' partition. The thing is I've got my softwares installed in 'D:\Program Files'. So my question is, will my programs work all right if I cut and paste the directory to another partition, and then move them back to a newly created partition (from the unallocated space left after extending 'C:\') with the same label ('D:\') as before.
I understand that there are registry pointers. I was wondering if they work at the same level of abstraction as that of the disk paths.
Thanks in advance!