apache 2.2 - Heartbleed, which specific services must be restarted?

Trying to figure out exactly what services should be restarted after patching openssl against Heartbleed. At least one post mentions restarting:

sshd, apache, nginx, postfix, dovecot, courier, pure-ftpd, bind, mysql

• Is there a command that can be run to see what running services are
  dependent on openssl?


• Is there a command to run against apache/nginx to see if the patch is active so the service doesn't need to be restarted?


• Should we just schedule downtime and reboot
  every server entirely?

EDIT: This post suggests using: lsof -n | grep ssl | grep DEL to display processes still using the old version of OpenSSL marked for deletion